Proguanil discontinued in the UK

Information for health professionals about discontinuation of proguanil and the resulting change to malaria recommendations

Both Paludrine (proguanil hydrochloride) and Paludrine/Avloclor (proguanil hydrochloride, chloroquine phosphate) Anti-Malarial Travel Pack have been discontinued in the UK. Once current stocks are exhausted, no further supplies will be available. This means that proguanil will no longer be available in the UK and will impact on the malaria recommendations for a small number of countries where the combination of chloroquine and proguanil was recommended for malaria prevention.

Supplies of Avloclor (chloroquine phosphate) are not affected.

As a result of this change in availability, our Country Information pages have been updated to recommend alternative antimalarial medication options.

Advice for health professionals

If chloroquine plus proguanil was recommended previously, an alternative malaria chemoprophylaxis regimen (i.e. atovaquone/proguanil or doxycycline or mefloquine), will now be listed on our Country Information pages. The UK Health Security Agency Advisory Committee on Malaria Prevention (ACMP) will update their guidelines in due course.

Health professionals who need further information regarding the Paludrine and Paludrine/Avloclor Travel Pack products are encouraged to contact Alliance Pharmaceuticals directly.

Contact details

Alliance Pharmaceuticals
01249 466 966
https://www.alliancepharmaceuticals.com